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Advances in Understanding Immune Dysfunction in Autism Spectrum Disorders – Dr Judy Mikovits



Increasing evidence highlights a role for immune dysfunction in the pathogenesis of autism spectrum disorders (ASD). A central tenet to our theory is that there is a critical threshold of immune activation and that chronic disruption of the critical balance of the immune response results in clinical disease. This threshold varies in different individuals and a progression of multiple hits from disparate antigens and toxins in a developing immune system in early life or an immune system during critical times of development such as puberty leads to a disease engine and a cytokine and chemokine storm of chronic overstimulation resulting in tissue damage. Crosstalk between immune responses to biotoxins and microorganisms leads to the development of neuroimmune disease in patients with deficits in detoxification, methylation, and immune response to pathogens. Conceptualizing the illness as an acquired immune deficiency suggests strategies for management and prevention.

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